First Vaccine vs. Traditional Vaccines vs. DNA Vaccines vs. RNA Vaccines

First Vaccine vs. Traditional Vaccines vs. DNA Vaccines vs. RNA Vaccines

When one is talking about vaccines, there are currently 4 different types of vaccines.  There are the first generation vaccines (the original SmallPox vaccine), traditional vaccines (the ones most people have gotten during childhood), DNA vaccines, and mRNA vaccines.

The COVID-19 vaccine falls into the category of mRNA vaccines, but since no vaccines using mRNA have been approved for human use anywhere in the world, at this point, the first vaccine to use this technology (and be accepted worldwide) is a “proof of concept”.  At the end, when a person plays the online slots of the “new” COVID-19 vaccine are they going to hit the jackpot or are they just going to end up with a whole row of nothing?

Smallpox, the first vaccine (1st Generation Vaccines)

During the American Revolution, the Smallpox virus affected a large number of the population.  Many people died.  Whole communities had to be quarantined to help contain the virus, but they were not in lockdown as they are today.  The lockdowns in those days had to do with other reasons.

An inoculation against SmallPox was considered very dangerous.  It was considered to be a new idea.  (Very similar to the fact that an RNA vaccine is considered a new idea today.)  People did not understand it, and it was quite risky.  Those that favor it say that it will give you a milder form of the pox, and prevent the most deadly type of infection.  But the inoculation itself caused great illness and even death.

First, people had to ingest mercury, a poison to their system.  Then a person must fast and purge for days.  Then when you are weak, and your blood is thin, you must brave the infection itself.  It was considered very dangerous.  But it was not SmallPox the person was being infected with.  It was CowPox, a relative of SmallPox, but in a much milder form.

It was discovered through observation that a person had caught CowPox (women who milked cows), that they became immune to the SmallPox (or caught a very mild form of it).  This is similar to today for people who have previously been exposed to milder forms of Coronavirus (SARS-CoV — the first one from 2003).

Those who had been exposed to that virus have either been immune or else they were asymptomatic to COVID-19 (the current version of the SARS virus, originally called SARS-Cov2).  Many people do not understand this relationship, because the WHO organization felt that people would panic if they knew that the current COVID-19 was related to the SARS from 2003.  So they chose a name that hid that relationship.

But back to SmallPox … even the people who got the vaccine were they were so weak that they passed out.  They still had a high fever, chills, too weak to get out of bed (all of the same stuff that people have with COVID-19 — and that was with the vaccine).  And, just as with COVID-19 (and most other viruses) children’s bodies were better able to handle the virus than adults, even adults in their 20s and 30s).   They also did not have over the counter medicines like Tylenol to help reduce fever and pain in the 1700s.

In 1779, in Sweden, 7200 people died of SmallPox per 1 million people.  With the COVID-19, 94 people die of COVID-19 per 1 million people.  In the US, it is 500 people die per 1 million people, but those rates are going down from the rates when the virus first began.  In 1871, in the Netherlands when there was another high outbreak, it was 4360 per 1 million people.

Vaccines between the 1950s to 2020s (2nd Generation Vaccines)

Thimerosal is a mercury-containing compound that prevents the growth of dangerous bacteria and fungus.  It is used as a preservative for flu vaccines in multi-dose vials to keep the vaccine free from contamination.  It is also used during the manufacturing process.

In 1999, as a precautionary measure, the US Public Health Service recommended removing thimerosal as a preservative from vaccines to reduce mercury exposure to infants as much as possible.  Today, except for some flu vaccines in multi-dose vials, no recommended childhood vaccines contain thimerosal as a preservative.

In all other recommended childhood vaccines, no thimerosal is present, or the amount is close to zero.  Only the Influenza vaccine in the multi-dose version contain thimerosal, but the single dose version does not.

In the past, multidose vaccines were the standard.  Once drug companies switched to a single-dose version, the preservative thimerosal was no longer needed.

DNA modifying vaccines (3rd Generation Vaccines)

DNA modifying vaccines have been in research and development since 1983.  In 2016, a DNA vaccine for the Zika virus went into clinical trials with 120 people between the ages of 18 and 35.  But the clinical trials never got beyond that point.

On the other hand, DNA vaccines have successfully gone into production for animals.  Specifically, there is a veterinary DNA vaccine to protect horses from the West Nile Virus.

The key technology with DNA vaccines is that they must penetrate the cell nucleus (crossing two membranes; the cytoplasm and the nucleus).  “The DNA must then be transcribed in the nucleus into nRNA before moving to the cytoplasm to stimulate antigen production.  This core complex pathway requires high doses of the vaccine and special, often painful delivery devices.” Electric shocks are used during the delivery and once inside the nucleus, DNA vaccines have a risk of permanently changing a person’s DNA.

My notes:  Even if the DNA vaccine was shown to not cause a problem with the actual patient, what about the next generation?  Males continuously produce sperm, so once DNA is modified in the body, the sperm is then modified.  This is may or may not also be true for women, who are born with all of their eggs.  But that does not mean that the generation after that would not be affected.

My view about DNA vaccines is that the “cure” is worse than the disease (unless you are talking about a person who is post-child-bearing age, above the age of 50).

RNA Vaccines (4th Generation Vaccines)

Research into RNA vaccines began around 2005, but as of today, no RNA vaccines have been approved by the FDA.

Unlike DNA vaccines, mRNA vaccines do not need to enter the nucleus, nor do they risk being integrated into the DNA (no changes to a person’s DNA).  These vaccines are directly translated into protein antigens.  mRNA vaccines are also 1/1000 the dose of DNA vaccines (which is another good thing).  Nor do they need specialized delivery systems (no electric shocks to get the vaccine).

The main disadvantage is that an mRNA vaccine may produce an unintended immune response.  For anybody who suffers from seasonal allergies or food allergies, you will know what I am talking about.

Story of my son:  My son has egg allergies.  He was given the MMRV vaccines (measles, mumps, rubella, and varicella) which is stored in egg whites (what my son was allergic to).  The result was that for two years, his egg allergy went into a hypersensitive mode where even a drop of eggs caused an allergic reaction.  Now, my son was fine.

But, the question that I have not seen anybody address (pharma companies or the government) is if a person suffers from seasonal allergies or food allergies is the risk of unintended immune response higher?  What about between people whose reactions are anaphylaxis (affects lungs and heart) vs. gastrointestinal reactions (stomach and intestines) vs. hives and psoriasis (skin reactions)?  From what I have seen, I do not think that the doctors are even asking those questions.

What is the difference between a DNA vaccine and an RNA vaccine?

  • Risk of DNA integration
    • DNA: Yes
    • RNA: No
  • Dose
    • DNA: mg
    • RNA: µg (1000x lower)
  • Factory size
    • DNA: Large
    • RNA: Small
  • Membrane Penetration
    • DNA: Cytoplasm & Nucleus
    • RNA: Cytoplasm only

What are the differences between traditional vaccines and RNA vaccines?

  • Development
    • Traditional: 10-15 years
    • RNA: 4-7 years
  • Process Development
    • Traditional: Customized for each vaccine
    • RNA: Standardized
  • Facility Scalability
    • Traditional: Bespoke for each vaccine
    • RNA: Single facility with bolt-on capacity
  • Costs
    • Traditional: $200 million – $1 Billion
    • RNA:  $100 – $200 million
  • Stockpiling
    • Traditional: High volume of the finished product requiring replenishment
    • RNA: Ability to stockpile library of APIs (low volume and long shelf life expected) and formula and finish as needed.  — Generally, 90% is standardized and the last 10% is customized as needed.
  • Potency
    • Traditional: Humoral response.  May require adjuvant
    • RNA: Humanoral and T Cell response.   Unlikely adjuvant.


At the current time (as of August 2020), Dr. Fauci predicts that a COVID-19 vaccine using this technology will only be 50% effective.  For a virus that has a death rate of 0.8%, from my non-professional level of medical knowledge, it does not seem worth it.

Plus, if people who have allergies (respiratory problems) are at most risk for the vaccine, those same people are going to be at the highest risk for the virus.  So it then becomes a gamble.  Are you going to die from the virus or die from the vaccine?

Not to mention, in my personal view, hydroxychloroquine plus zinc is very effective when given early (within the first 5 days of symptoms showing themselves).  So current death rates are a fraud because doctors are being required to fight a virus with, essentially, one hand tied behind their backs.

So then that leads to the question, why is the government doing this?  And the answer is — look closely at the chart above.  This COVID-19 vaccine has nothing to do with the treatment of the COVID-19 virus, and it has everything to with a “proof of concept”.  That is why the government and the pharma companies are pushing onto the American people (and the world) this vaccine instead of a cure.

About the author

Donna Miller

Donna is one of the oldest contributors of Gruntstuff and she has a unique perspective with regards to Science which makes her write news from the Science field. She aims to empower the readers with the delivery of apt factual analysis of various news pieces from Science. Donna has 3.5 years of experience in news-based content creation, and she is now an expert at it. She loves journalism, and that is the reason, she moved from a web content writer to a News writer, and she is loving it. She is a fun-loving woman who has very good connections with every team member. She makes the working environment cheerful which improves the team’s work productivity.

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