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Single dose of Pfizer, Moderna COVID vaccine nearly as effective as two: study

Single doses of the Pfizer and Moderna vaccines are greater than 92 % effective in stopping COVID-19 sickness after two weeks, Canadian researchers are saying.

The FDA’s personal knowledge present {that a} single shot of the BioNTech-Pfizer vaccine is 92.6 % effective after two weeks, and a single Moderna jab is 92.1 % effective, the researchers observe within the New England Journal of Drugs.

Getting that second shot of Pfizer’s vaccine hikes the efficacy solely marginally, to 94 %, based on a separate study based mostly on real-world knowledge from Israel’s vaccination program.

And so the prescribed second doses must be given as an alternative to these in precedence teams who’re nonetheless ready for his or her first shot, “given the present vaccine scarcity,” the researchers urge.

“With such a extremely protecting first dose, the advantages derived from a scarce provide of vaccine might be maximized by deferring second doses till all precedence group members are provided a minimum of one dose,” the researchers say in a letter to the NEJM editors.

“There could also be uncertainty in regards to the length of safety with a single dose,” the researchers stated.

“However the administration of a second dose inside 1 month after the primary, as advisable, offers little additional benefit within the brief time period, whereas high-risk individuals who may have acquired a primary dose with that vaccine provide are left fully unprotected.”

A health worker receives a dose of the Pfizer-BioNTech vaccine against COVID-19 on February 18, 2021.
A well being employee receives a dose of the Pfizer-BioNTech vaccine towards COVID-19 on Feb. 18, 2021.
RAUL ARBOLEDA/AFP by way of Getty Photos

The letter was written by Dr. Danuta M. Skowronski of the British Columbia Centre for Illness Management in Vancouver and Dr. Gaston De Serres of the Institut Nationwide de Sante Publique du Quebec in Quebec Metropolis.

In a letter to NEJM responding to the 2 researchers, Pfizer harassed that “different dosing regimens” nonetheless should be evaluated.

About the author

Donna Miller

Donna is one of the oldest contributors of Gruntstuff and she has a unique perspective with regards to Science which makes her write news from the Science field. She aims to empower the readers with the delivery of apt factual analysis of various news pieces from Science. Donna has 3.5 years of experience in news-based content creation, and she is now an expert at it. She loves journalism, and that is the reason, she moved from a web content writer to a News writer, and she is loving it. She is a fun-loving woman who has very good connections with every team member. She makes the working environment cheerful which improves the team’s work productivity.

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